Mechanisms and Regulation of Cell Death and Autophagy

Description

The student should acquire theoretical knowledge and practical skills within the field of regulated cell death (RCD) and autophagy to achieve the following learning outcomes:

Distinguish regulated cell death (RCD) from accidental cell death as well as the different RCD processes in relation to morphological, biochemical and molecular characteristics.;
Describe the intrinsic and extrinsic apoptotic pathways and main processes of regulated necrosis;
Identify the main components/regulators of the apoptosis process, in particular the structural and functional properties of Bcl-2 family proteins;
Discuss the importance of autophagy in physiological and pathological conditions;
Identify the main components of the autophagic and mitophagic processes;
Recognize the relevance of yeast as a complementary model to cell lines to understand the mechanisms underlying cell death regulation;
Discuss the physiological importance of RCD in the health and disease of multicellular organisms.

Number of hours

Autonomous work: 49 Hours;

Classes:

12 hours – Laboratory Practice;
9 hours – Síncrono;

6 hours – Theoretical;

8 hours – Theory Practice.

Target group

Participants who have already completed a bachelors degree in Biology, Biochemistry, Environmental Sciences, Health Sciences, Biotechnology, or related fields.

Number of participants

MIN – 8; MAX – 20.

Prerequisites

The course is designed for individuals with a bachelor's degree who seek to gain solid scientific and experimental skills at the specialization level, focusing on Regulated Cell death and Autophagy.